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It may offer benefits for metabolic health and improving energy utilisation

The results can be spectacular, including in rare instances the complete disappearance of soft tissue calcifications from small peripheral arteries (see Figure 15b)

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Recent structural studies using cryo-electron microscopy (cryo-EM) have elucidated the structure of the DDD or DDD-Ube2e2 complex, with one report further showing that the assembly and function of CRL4 DET1-COP1 require a network of specific and flexible interactions-DET1 recruits Ube2e family E2s, DDA1 stabilizes DET1 and enables COP1 recruitment, and these coordinated interactions allow the assembly of the functional ligase complex 23,24